Neurobiologist Dr. David Styles is one of the gameís central characters: since losing his wife in a horrible accident several years ago, David has become a recluse, seldom leaving Dread Hill House, his English country estate. But when student and part-time street performer Samantha Everett shows up at his doorstep, she unexpectedly becomes his new assistant. Hailing from America, she has been travelling through most of Europe the last couple years searching for refuge and a well paid job. Her first task: involves recruiting six test subjects from Oxford University for one of Stylesí planned experiments. The experiment starts off innocently enough, but then inexplicable incidents start mounting including a visit from Styles dearly departed wife. Now itís up to Sam and Dr. Styles to solve the mysteries of Dread Hill House. In Gray Matter, the player takes control of Dr. David Styles as well as Samantha Everett as they are trying to unveil secrets and find the truth.