Check out juggles from Kokoro, Kasumi, Jann Lee, Akira, Leifang and Rig.
You can normally hold during Critical and slow escapes still work, but DOA5 also has more guaranteed moves. When you get your opponent in a sit-down stun or with their back turned, that's your chance for a huge combo. And if you can flow into a Critical Burst, you have even more options for combos. I think these features will really help set DOA5 apart.