The King of Fighters Ex: Neo Blood features fast-moving 2-D fighting action, with team, single, survival, practice, and two-player modes. The game includes lots of characters from the KOF franchise and a new character. It also offers multiple fighting styles, 18 fighters, six strikers, and six hidden characters (four strikers and two bosses). The story of Neo Blood follows the competition in the King of Fighters Tournament. After the battle with Orochi, an unknown host brings together the legendary fighters of the day to compete for the championship. Despite their suspicions of an evil scheme brewing behind the event, the fighters are ready to enter the arena, prepared to determine the true King of Fighters.