Worms 2008 features a story of intergalactic Worm travellers exploring their solar system. The improved single-player campaign missions feature varying objectives to keep the player on their toes as they fight to defend installations, repair space crafts, collect rare minerals and battle to the death against alien races. With the space setting comes a host of new weapons, including the Impact Frag, Atom Packs and Cluster Frags, which are based around the classic Worms weapons but share all new artwork and names with Worms: A Space Oddity, released earlier this year for Nintendo Wii™.

Worms 2008 also features all new graphics and new animations, including new looks for the opponent alien races. Advanced landscape generation systems have enabled more realistic levels. Graphical effects like smoke trails help to bring shots to life, while multi-layered parallax particles enhance the depth of field effect and have direct impact from gameplay, reacting to the direction and strength of the wind.