Evil Dead: Regeneration follows along with Ash, the hero of the Evil Dead movies. Ash is the only survivor of the evils unleashed by the Necronomicon, that night in the cabin. Ash is blamed for it and sent to the Sunny Meadows institute for the criminally insane. He thinks he's safe and can rest now, but the perverted experiments of Dr. Reinhard are about to change that.
- Hell-bent on using science to harness the Necronomicon's powers, the mad doctor unleashes the book's all-powerful Evil on the world
- Releasing a new slew of Deadites, monsters and spirits, twisting reality into a hellish strudel -- leaving Ash to get his chainsaw and shotgun to fight them off again